Don Wesley Arnold, Ph.D.
Don is a successful scientist and business manager with strong technical background and over 17 years of experience in technology development for the life sciences including 15 years of entrepreneurial experience in starting, operating, growing and selling a start-up high-tech business serving the life science markets. During this time, he has gained experience ranging from experimental physical chemistry to microfluidics to business development, R&D in a national laboratory environment, intellectual property development and management, technology transfer, merger and acquisition, integration into a global organization and manufacturing transfer.
Specialties:
Technical:
Micro- and Nanofluidics and Microfabrication
Electrokinetic pumping and flow control
Chemical Analysis - Microanalytical System integration
Sensitive Detection - optical and electrochemical
Biological assays - flow and bead-based
Microscale sample preparation and extraction
Ion spectroscopy, vacuum systems, laser spectroscopy
Business:
General Management
M&A and Integration
Project management
Business development
Proposal writing
Patent preparation and prosecution
Intellectual property licensing
University of California, Berkeley
NSF Fellow
Thesis title: Study of Radicals, Clusters and Transition State Species by Anion Photoelectron Spectroscopy
Cornell Tradition Fellow
“Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry”, Germán Augusto Gómez-Ríos, Chang Liu, Marcos Tascon, Nathaly Reyes-Garcés, Don W. Arnold, Thomas R. Covey, and Janusz Pawliszyn, Analytical Chemistry, 89, 3805 (2017).
“Evaluation of micro ultra high pressure liquid chromatography for pharmaceutical analysis”, Yang, M., Gong, X. Schafer W., Arnold, D., and Welch, C. J., Analytical Methods, 5, 2178 (2013).
“microLC-MS-MS: The Future of Bioanalysis” Editorial in Bioanalysis 2013 with Shane Needham.
“HPLC at the Micro Scale”, Arnold, D. W., Innovations in Pharmaceutical Technology, 31, 24 (2009).
“On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets”, Beer, N. R., Wheeler, E. K., Houghton, L. L., Watkins, N., Nasarabadi, S., Hebert, N., Leung, P., Arnold, D. W., Bailey, C. G. and Colston, B. W., Analytical Chemistry, 80, 1854 (2008).
“Microchip separations of protein biotoxins using an integrated hand-held device”, Fruetel, J. A., Renzi, R. F., Vandernoot, V. A., Stamps, J., Horn, B. A., West, J. A., Ferko, S., Crocker, R., Bailey, C. G., Arnold, D. W., Wiedenman, B., Choi, W. Y., Yee, D., Shokair, I., Hasselbrink, E., Paul, P., Rakestraw, D., Padgen, D., Electrophoresis 26, 1144 (2005).
"On-Chip Packed Channel Separations", Fintschenko, Y., Ngola, S. M., Shepodd, T. J., and Arnold, D. W., Micro Total Analysis Systems 2000, edited by A. van den Berg, W. Olthuis, and P. Bergveld Kluwer Academic Publishers, Dordrecht, 2000, pp. 411-414.
"Electrokinetic Pump Application in Micro-Total Analysis Systems: Mechanical Actuation to HPLC", Paul, P. H., Arnold, D. W., Neyer, D. W., and Smith, K. B., Micro Total Analysis Systems 2000 , edited by A. van den Berg, W. Olthuis, and P. Bergveld Kluwer Academic Publishers, Dordrecht, 2000, pp. 583-590.
"On-chip chiral and achiral separation of amphetamine and related compounds labeled with 4-fluoro-7-nitrobenzofurazane", Wallenborg, S. R., Lurie, I. S., Arnold, D. W., and Bailey, C. G., Electrophoresis, 21, 3257 (2000).
"Single Organelle Analysis with Integrated Chip Electrophoresis and Optical Tweezers", Wheeler, A. R., Morishima, K., Arnold, D. W., Rossi, A. B., and Zare, R. N., Micro Total Analysis Systems 2000, edited by A. van den Berg, W. Olthuis, and P. Bergveld Kluwer Academic Publishers, Dordrecht, 2000, pp. 25-28.
"Integrated optical systems for excitation delivery and broadband detection in microfluidic electrochromatography", Kemme, S. A., Warren, M. E., Sweatt, W. C., Wendt, J. R., Bailey, C. G., Matzke, C. M., Allerman, A. A., Arnold, D. W., Carter, T. R., Asbill, R. E., and Samora, S., Vol. 3952, SPIE, 2000, pp. 375-383.
“Survival of HCl(v=2) in trapping-desorption from MgO(100)”, Korolik M., Suchan, M. M. Johnson, M. J., Arnold D. W., Reisler, H. and Wittig C., Chemical Physics Letters 326, 11 (2000).
"SDS capillary gel electrophoresis of proteins in microfabricated channels", Yao, S., Anex, D. S., Caldwell, W. B., Arnold, D. W., Smith, K. B., and Schultz, P. G., Proceedings of the National Academy of Sciences of the United States of America, 96, 5372 (1999).
"Fabrication of high performance microlenses for an integrated capillary channel electrochromatograph with fluorescence detection", Wendt, J. R., Warren, M. E., Sweatt, W. C., Bailey, C. G., Matzke, C. M., Arnold, D. W., Allerman, A. A., Carter, T. R., Asbill, R. E., and Samora, S., Journal of Vacuum Science & Technology B, 17, 3252 (1999).
"Fluorescence-based visualization of electro-osmotic flow in microfabricated systems", Arnold, D. W. and Paul, P. H., Vol. 3877, SPIE, 1999, pp. 174-179.
"Characterization of porous polymer monoliths as flow restrictors for capillary electrophoresis on a chip", Fintschenko, Y., Arnold, D. W., Peters, E. C., Svec, F., and Frechet, J. M., Vol. 3877, SPIE, 1999, pp. 202-209.
"Integrated micro-optical fluorescence detection system for microfluidic electrochromatography", Warren, M. E., Sweatt, W. C., Wendt, J. R., Bailey, C. G., Matzke, C. M., Arnold, D. W., Kemme, S. A., Allerman, A. A., Carter, T. R., Asbill, R. E., and Samora, S., Vol. 3878, SPIE, 1999, pp. 185-192.
“Trapping-Desorption and Direct-Inelastic Scattering of HCl from MgO(100)”, Korolik, M., Arnold, D. W., Johnson, M. J., Suchan, M. M., Reisler, H. and Wittig C., Chemical Physics Letters, 284, 164 (1998).
"Electrokinetic Generation of High Pressure using Porous Microstructures", Paul, P. H., Arnold, D. W., and Rakestraw, D. J., Micro-Total Analysis Systems 1998, edited by D. J. Harrison and A. van den Berg, Kluwer Academic, 1998, pp. 49-52.
"Microseparations and Microfluidic Studies”, Arnold, D. W., Bailey, C. G., Garguilo, M. G., Matzke, C. M., Wendt, J. R., Sweatt, W. C., Kravitz, S. H., Warren, M. E., and Rakestraw, D. J., Micro-Total Analysis Systems 1998, edited by D. J. Harrison and A. van den Berg Kluwer Academic, 1998, pp. 435-438.
“The effect of translational energy on collision-induced dissociation of highly excited NO2 on MgO(100)”, Arnold, D. W., Korolik, M., Wittig C. and Reisler, H., Chemical Physics Letters, 282, 313 (1998).
“Study of HCO2 and DCO2 by negative ion photoelectron spectroscopy”, Kim, E.H. et al., Journal of Chemical Physics 103, 7801 (1995).
Study of halogen--carbon dioxide clusters and the fluoroformyloxyl radical by photodetachment of X-(CO2) (X=I, Cl, Br) and FCO2, Arnold, D.W. et al., Journal of Chemical Physics, 102, 3493 (1995).
“Study of I-(CO2)n, Br-(CO2)n, and I-(N2O)n clusters by anion photoelectron spectroscopy”, Arnold, D.W. et al., Journal of Chemical Physics, 102, 3510 (1995).
“Spectroscopy of the transition state: Elementary reactions of the hydroxyl radical studied by photoelectron spectroscopy of O-(H2O) and H3O2-”, Arnold, D.W., Xu, C. & Neumark, D.M., Journal of Chemical Physics, 102, 6088 (1995).
“Study of N2O2 by photoelectron spectroscopy of N2O2-”, Arnold, D.W. & Neumark, D.M., Journal of Chemical Physics, 102, 7035 (1995).
“Study of low-lying electronic states of ozone by anion photoelectron spectroscopy of O3-”, Arnold, D.W. et al., Journal of Chemical Physics, 101, 912 (1994).
“Anion photoelectron spectroscopy of small indium phosphide clusters (InxPy-; x,y=1-4)”, Xu, C. et al., Journal of Chemical Physics, 101, 5406 (1994).
“The Transition State of the F + H2 Reaction,” David E. Manolopoulos et al., Science 262, 5141, 1852 (1993).
“Experimental and theoretical studies of the F+H2 transition state region via photoelectron spectroscopy of FH2-”, Bradforth, S.E. et al., Journal of Chemical Physics, 99, 6345 (1993).
“Photoelectron spectroscopy of CN-, NCO-, and NCS-”, Bradforth, S.E. et al., Journal of Chemical Physics, 98, 800 (1993).
“Anion photoelectron spectroscopy of iodine-carbon dioxide clusters”, Arnold, D.W. et al., Journal of Chemical Physics, 97, 9468 (1992).
“Examination of the 2A2’ and 2E` states of NO3 by ultraviolet photoelectron spectroscopy of NO3-”, Weaver, A. et al., Journal of Chemical Physics,. 94, 1740 (1991).
“Vibrationally resolved spectra of C2-C11 by anion photoelectron spectroscopy”, Arnold, D.W. et al.. Journal of Chemical Physics, 95, 8753 (1991).
“Examination of the Br+HI, Cl+HI, and F+HI hydrogen abstraction reactions by photoelectron spectroscopy of BrHI-, ClHI-, and FHI-”, Bradforth, S.E. et al., Journal of Chemical Physics, 92, 7205 (1990).
Several Patents and Patent Applications
“Precision Flow Control System” US 8,685,218 (granted 4/2014), Paul, P. H., Rehm, J. E., Arnold D. W.
“Microfluidic Connections”, US 8,021,056 (granted 9/2011) Arnold, D. W., Hencken, K. R., Datwani, S. S., Leung, P. P. Cyr, D. R., Rehm, J. R.
“Precision Flow Control System” US 7,927,477 (granted 4/2011), Paul, P. H., Rehm, J. E., Arnold D. W.
“Microfluidic detection device having reduced dispersion and method for making same”, US 7,925,125, (granted 4/2011) Cyr, D. R., Farrow, R. L., Arnold, D. W.
“Microfluidic Connections”, US 7,802,923 (granted 9/2010) Arnold, D. W., Hencken, K. R., Datwani, S. S., Leung, P. P. Cyr, D. R., Rehm, J. R.
“Electroosmotic Flow Controller”, US 7,695,603 (granted 4/2010) Paul, P. H., Arnold, D. W., Bailey, C. G.
“Microfluidic Device”, US 7,575,722 (granted 8/2009), Arnold, D. W
“Flow Control Systems”, US 7.597,790 (granted 10/2009), Neyer, D. W., Paul, P. H., Arnold, D. W., Bailey, C. G.,
“Electrokinetic pump driven heat transfer system”, US 7,559,356 (granted 7/2009), Paul, P. H., Anex, D. S., Arnold, D. W.
“Fuel Cell System with Electrokinetic Pump”, US 7,521,140 (granted 4/2009), Arnold, D. W, Paul, P. H. Anex, D. S.
“Precision flow control system”, IN 223349, (granted 9/2008), Paul, P. H., Rehm, J. E., Arnold D. W.
“Precision flow control system”, US 7,465,382 (granted 4/2008), Paul, P. H., Rehm, J. E., Arnold D. W.
“Processing of particles”, US 7,175,810, 02/07, Arnold, D. W., Rakestraw, D. J., Paul, P. H. Leung, P.
“Particulate processing system”, US 7,220,592, 05/07, Rakestraw, D. J., Arnold, D. W., Paul, P. H.
“Microfluidic detection device having reduced dispersion and method for making same”, US 7,336,860, 05/07, Cyr, D. R., Farrow, R. L., Arnold, D. W.
“Method and apparatus for controlling cross contamination of microfluid channels”, US 6,994,826, 02/06, Hasselbrink, Jr., E. F., Rehm, J. E., Paul, P. H., Arnold, D. W.
“Microfluidic detection device having reduced dispersion and method for making same”, US 7,050,660, 05/06, Cyr, D. R., Farrow; R. L., Arnold, D. W.
“Particle-based check valve”, US 6,802,331, 10/2004, Arnold, D. W., Rakestraw, D. J., Rehm, J.
“Passive injection control for microfluidic systems”, US 6,833,068, 12/04, Paul, P. H., Arnold, D. W., Neyer, D. W.
“Flowmeter for pressure-driven chromatography systems”, US 6,532,802, 03/03, Paul, P. H., Arnold, D. W.
“Electrokinetic high pressure hydraulic system”, US 6,572,749, 06/03, Paul; P. H., Rakestraw, D. J., Arnold, D. W., Hencken, K. R., Schoeniger, J. S., Neyer, D. W.
“Method of filling a microchannel separation column”, US 6,444,150, 09/02, Arnold, D. W.
“Flowmeter for pressure-driven chromatography systems”, US 6,460,420, 10/02, Paul, P. H., Arnold, D. W.
“Microfluidic channel fabrication method”, US 6,210,986, 04/01, Arnold, D. W., Schoeniger, J. S., Cardinale, G. F.
“Electrokinetic high pressure hydraulic system”, US 6,277,257, 08/01, Paul, P. H., Rakestraw, D. J., Arnold; D. W., Hencken, K. R., Schoeniger, J. S., Neyer, D. W.
“Method for eliminating gas blocking in electrokinetic pumping systems”, US 6,287,440 09/01, Arnold, D. W., Paul, P. H., Schoeniger, J. S.
“Sample injector for high pressure liquid chromatography”, US 6,290,909, 09/2001, Paul, P. H., Arnold, D. W., Neyer, D. W.
Several other applications in process that have not yet published.